Based on the effect of PRC1 on macrophages (Su et al., 2019), we hypothesize that hsa_circ_0004913 acts as the hsa-miR-182-5p sponge to relieve PRC1 inhibition, leading to a decrease in M1 macrophages and an increase in M2 macrophage infiltration, thereby promoting the progression of HCC. This evidence concerns the gene PRC1 and hepatocellular carcinoma.