EZH2 and hepatocellular carcinoma: Among the six hub DEmRNAs, EZH2 has been demonstrated to be highly expressed in HCC, and injection of EZH2 inhibitor GSK126 induces CXCL10 production from macrophages and causes plasma cell polarization, inhibition of the antitumor T cell response, and hepatoma growth (Wei et al., 2019).