AKT1 and cancer: Previous studies of cancer have demonstrated the role that COL3A1 can play in the proliferation of cancer cells (Qiu et al., 2015; Xu et al., 2018), Furthermore, the overexpression of COL3A1 can lead to a significant decrease in the phosphorylation of the AKT/mTOR pathway (Kuivaniemi and Tromp, 2019), a pathway that is important for lactation (Wang et al., 2014).