Furthermore, these ECM regulators have also been reported to be important in the remodeling process in the left ventricle after experimentally induced myocardial infarction in mice, where the local endogenous control of MMPs by TIMP1 was suggested to be important for the ECM structure, as well as myocardial function and myocyte growth (Creemers et al., 2003). This evidence concerns the gene TIMP1 and myocardial infarction.