An SNP of the TMPRSS2 gene (rs12329760 C>T; Met160Val) present in an exonic splicing enhancer srp40 site, which is highly conserved across mammals, has been found to be associated positively with TMPRSS2–ERG fusion by translocation due to an increased chance of exon skipping in prostate cancer (Bhanushali et al., 2018). The gene discussed is ERG; the disease is Familial prostate cancer.