An SNP of the TMPRSS2 gene (rs12329760 C>T; Met160Val) present in an exonic splicing enhancer srp40 site, which is highly conserved across mammals, has been found to be associated positively with TMPRSS2–ERG fusion by translocation due to an increased chance of exon skipping in prostate cancer (Bhanushali et al., 2018). This evidence concerns the gene TMPRSS2 and Familial prostate cancer.