In summary, ACVRL1 and ACVR1B gene overlapped QTLs linked to CD4-positive leukocyte percentage (CD4LP), C3c concentration (C3C), and Hemolytic complement activity (alternative pathway) (AH50), while, GGT5 and GGT1 gene overlapped QTLs linked to Interferon-gamma to interleukin-10 ratio (IFNGIL10), Calcium level (BCAL), Creatinine level (CREAT), Potassium level (BPOTASS), C3c concentration (C3C), Haptoglobin concentration (HAPT), and Melanoma susceptibility (MELAN). The gene discussed is HP; the disease is freckles.