VCAM1 and acute respiratory distress syndrome: In acute lung injury (ALI and ARDS) after trauma, systemic and pulmonary chemotaxins and complement activation products result in upregulation of endothelial adhesion molecules, including e-/p-selectin and vascular cell adhesion molecule 1 (VCAM-1) (59, 60), and subsequent migration of neutrophils into the interstitium and alveolar space.