IRF3 and infection: In teleost fish, our previous study showed that zebrafish TBK1_tv1 and TBK1_tv2 isoforms inhibited RIG-I-, MAVS-, TBK1-, and IRF3-mediated activation of IFN promoters in response to SVCV infection, disrupted the formation of a functional TBK1–IRF3 complex, and impeded the phosphorylation of IRF3 mediated by TBK1 (18).