In this study, by using the patient cohorts from TCGA database, we discovered that HNSCC patients with a higher abundance of γδ T cells had prolonged overall survival, suggesting that γδ T cells were of great prognostic values for HNSCC, and were highly correlated with CD8+ T cell and CD4+ T cell infiltration in the TME. Here, CD4 is linked to head and neck squamous cell carcinoma.