TLR9 and Herpesviridae infectious disease: Of these, TLR3, TLR7, TLR8, and TLR9 contribute to antiviral immunity: TLR3 binds to double-stranded viral RNA; TLR7 and 8 detect single-stranded RNA viruses; and TLR9, which recognizes unmethylated cytosine-guanine (CpG) motifs in bacterial genomes, can also respond to herpesvirus infection.