Anti-colitis and anti-tumor effect (decrease the expression of cleaved CASP1, IL-lβ, mitochondrial membrane potential collapse, and PI3KCA–AKT1–mTOR–RPS6KB1 pathway; increases the disruption of NLRP3–PYCARD–CASP1 complex assembly and mitophagy in macrophages; inactivates the NLRP3 inflammasome; and induces autophagy). Here, PYCARD is linked to colitis.