Anti-inflammatory effect (increases the interaction with cysteine 279 of NLRP3 in NACHT domain; blocks the interaction between NLRP3 and NEK7; inhibits NLRP3 inflammasome assembly and activation; reduces peritonitis, gouty arthritis, and type 2 diabetes; and inhibits NLRP3 activation). This evidence concerns the gene NEK7 and gout.