Due to SARS-CoV-2 viral genome sequencing similarities with MERS-CoV and SARS-CoV-1 (95), it is possible that similar mechanism of inhibition of TPC1 and TPC2 channel be effective in COVID-19, aiding in the reduction of viral replication (96).Interestingly, NAR can inhibit the activity of TPC1 and TPC2 both in humans and plants (97). This evidence concerns the gene TPCN1 and COVID-19.