Due to SARS-CoV-2 viral genome sequencing similarities with MERS-CoV and SARS-CoV-1 (95), it is possible that similar mechanism of inhibition of TPC1 and TPC2 channel be effective in COVID-19, aiding in the reduction of viral replication (96).Interestingly, NAR can inhibit the activity of TPC1 and TPC2 both in humans and plants (97). The gene discussed is TPCN2; the disease is COVID-19.