Recently, transcriptomic analyses demonstrated that pro-angiogenic genes including vegfa, itgb1, il1b, mmp14, and mmp9 as well as genes encoding other cell adhesion molecules, such as ilgals1 and igals3bp, are upregulated in TANs (62), further confirming a prominent role of neutrophils in promoting tumor angiogenesis. This evidence concerns the gene IL1B and neoplasm.