MiR-200b-3p regulates cell proliferation and apoptosis by targeting of Sp1 transcription factor (SP1) (43), induces apoptosis by regulating NF-κB pathway in BC cells (44), regulates CRC progression and metastasis by modulating the expression of ZEB1 (45), and regulates the self-renewing divisions by lessening Notch signaling in pancreatic cancer stem cells (46). This evidence concerns the gene ZEB1 and familial pancreatic carcinoma.