The causes of globozoospermia are genetic and, as far as we are currently aware, involve mutations in three genes, SPATA16 (spermatogenesis associated 16), PICK1 (protein interacting with PRKCA 1) and DPY19L2 (DPY-19 like 2) with the latter being dominant (16). The gene discussed is DPY19L2; the disease is Globozoospermia.