The incidence of these mutations varies from population to population but a recent analysis of North African males suggested that AURKC mutations were the most common, comprising 2.7% of the infertile male population compared with 1.2% exhibiting DPY19L2-dependent globozoospermia and anticipated rates of 1.6% exhibiting Klinefelter syndrome and 0.23% with Y-chromosome deletion (19). This evidence concerns the gene DPY19L2 and Globozoospermia.