TP53 and germ cell tumor: Gains of chromosome arm 12p and aneuploidy are nearly universal in germ cell tumors (65) while primary testicular lymphomas involve near-uniform loss of CDKN2A (cyclin dependent kinase inhibitor 2A) with rare TP53 (tumor protein p53) mutations as well as 9p24.1/PD-L1/PD-L2 copy number alterations and additional translocations of these loci (66).