The Ingenuity Pathway Analysis revealed that nine of the top 10 miRNA identified here showed functional connectivity as part of a regulatory network of genes predominantly associated with central regulators of inflammation through tumour necrosis factor (TNF) and interleukin 6 (IL6), though serum levels of both have been reported not to differ between PCOS and control women (43). This evidence concerns the gene IL6 and polycystic ovary syndrome.