One-way ANOVA analysis comparing differences for each of FGF19, 21, 23, and fetuin-A at the 3 time points of baseline, 180 and 300 min within the control group or within the PCOS groups showed that insulin infusion significantly increased the plasma concentrations of FGF21 (P < 0.05) in both PCOS and control women by 77 and 63%, respectively (P < 0.01); decreased FGF19 was seen only in the control group as assessed by one-way ANOVA comparing all the timepoints within control group, and there were no effects on plasma levels of FGF23 or fetuin-A in either groups (Table 1). Here, FGF21 is linked to polycystic ovary syndrome.