Our findings of reduced parallel diffusivity in white matter tracts of MOG-IgG+ patients compared to HC are complemented by previous studies investigating C57BL/6 mice with MOG-induced experimental autoimmune encephalomyelitis (EAE) that showed significant parallel diffusivity reduction within optic nerves (53) and within the spinal chord (54) with significant associations to EAE clinical scores and greater amounts of axonal damage as confirmed by quantitative staining. The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.