MAPT and Alzheimer disease: Two more indirect tau–nucleus interactions were recently presented: Autosomal-dominant FTD-tau mutations were shown to cause microtubule-mediated deformation of the nuclear membrane in human induced pluripotent stem cell (iPSC)-derived neurons (131), which resulted in defective NCT, and rod-like cytoplasmic tau aggregates at the nuclear envelope were shown to distort the nuclear membrane in striatal neurons in HD and in pre-tangle neurons in AD, and in mice expressing FTD-mutant tauP310S (37, 137, 138).