They found that miR-30e expression was increased, while ZDHHC21 expression, which they identified as a major palmitoyl acyltransferase involved in palmitoylation of 5-HT1AR, was reduced in PFC of MDD suicide subjects, suggesting that 5-HT1AR palmitoylation may be key to MDD pathogenesis and treatment. Here, ZDHHC21 is linked to major depressive disorder.