CDH5 and acute myocardial infarction: Aiming to identify the mechanism of EC proliferation post-ischaemia, Manavski et al. (2018), utilised Confetti fl/wild type (wt) cadherin 5 (Cdh5)- CreERT2 mice and revealed that ischaemia-induced vascularisation post-acute myocardial infarction (AMI) is mediated by clonally expanded ECs.