In a mouse model of cisplatin-induced AKI, neutrophil infiltration into the kidney and the expression of IL-1β, IL-18, and IL-6 were increased; however, neutrophil depletion and blocking these cytokines did not protect against ischemia injury (Faubel et al., 2007; Bolisetty and Agarwal, 2009). The gene discussed is IL1B; the disease is acute kidney injury.