MMP2 and Hirsutism: In previous studies, phenotypic comparisons of human and murine MMP-2 deficiency have been mostly limited to clinical symptoms (including inflammation and pain in joints, a progressive decrease in bone mineral density and articular cartilage destruction), associated pathologies (such as congenital cardiac valve defects, dwarfism and hirsutism) and physical features (notably, craniofacial defects) observed in the murine and human conditions (Martignetti et al., 2001; Mosig et al., 2007; Castberg et al., 2013; Mosig and Martignetti, 2013; Bhavani et al., 2016; Fernandez-Patron et al., 2016).