Chronic inflammation, as present in MMP-2 deficiency (Martignetti et al., 2001; Mosig et al., 2007; Tuysuz et al., 2009; Castberg et al., 2013; Mosig and Martignetti, 2013; Bhavani et al., 2016; Fernandez-Patron et al., 2016), alters the balance between osteoclasts and osteoblasts favoring more bone resorption which then leads to osteoporosis (Hardy and Cooper, 2009). This evidence concerns the gene MMP2 and osteoporosis.