MMP2 and Torg-Winchester syndrome: In humans, deficiency of MMP-2 due to biallelic inactivating mutations in the MMP2 gene causes a complex inflammatory syndrome comprising multicentric osteolysis, nodulosis, and arthropathy (MONA), (MIM# 259600–also known as Torg Syndrome or Torg-Winchester Syndrome), cardiac valve defects, dwarfism and hirsutism (Martignetti et al., 2001; Mosig et al., 2007; Castberg et al., 2013; Mosig and Martignetti, 2013; Bhavani et al., 2016; Fernandez-Patron et al., 2016).