MMP2 and hyperinsulinemic hypoglycemia, familial, 4: Among the serum components found to be dysregulated in both human and murine MMP-2 deficiency, bioactive cortisol and several pro-inflammatory cytokines involved in bone loss (Canalis and Delany, 2002; Weitzmann et al., 2002; Toraldo et al., 2003; Lee et al., 2009), were significantly elevated.