To determine whether the dysregulated cytokines observed in the case of human MMP-2 deficiency are also dysregulated in murine MMP-2 deficiency, we measured the levels of thirty-two cytokines and chemokines in the plasma of age- and sex matched MMP-2 knockout (Mmp2–/–) mice (n = 4) and compared them to wild type (WT) (n = 4). Here, MMP2 is linked to hyperinsulinemic hypoglycemia, familial, 4.