Berberine could attenuate cardiac hypertrophy associated with enhanced autophagy via inhibiting activation the mechanism of the mammalian target of rapamycin (mTOR), extracellular signal-regulated kinase (ERK1/2), and p38 mitogen-activated protein kinase (MAPK) phosphorylation (Li et al., 2014). The gene discussed is MTOR; the disease is cardiac hypertrophy.