NLRP3 and cystic fibrosis: Contrariwise, the exposition to P. aeruginosa strains displayed extensive mitochondrial swollen and fragmentation with derangement of cristae in CF airway epithelial cells, resulting in Δψ loss, excessive O2- production, and nod-like receptor 3 (NLRP3) inflammasome activation (Rimessi et al., 2015).