Pharmacological MCU inhibition, mediating KB-R7943, attenuated in vitro and in vivo the P. aeruginosa-dependent mitochondrial dysfunction and hyperinflammation in CF lung, controlling UPRmt and NLRP3 inflammasome activation (Figure 2, calcium) (Rimessi et al., 2020b). This evidence concerns the gene MCU and cystic fibrosis.