IL6 and autoimmune disease: With the help of the body’s immune function, it has direct and indirect dual anti-cancer effects on the same tumor, causing hemorrhage and necrosis of nutritional blood vessels, inducing IL-2 and IL-6 production, promoting the activity of coagulation factors and tissue factors, and participating in the pathological damage of certain autoimmune diseases (Phan-Lai et al., 2016; McGregor et al., 2019).