Furthermore, most of the strains of Streptococcus anginosus reported to infect patients with CGD (Falcone and Holland, 2013) can also cause respiratory exacerbations in CF (Grinwis et al., 2010) and are low H2O2 producers, consistent with the concept that neutrophils in the CF airway environment may have a functional NADPH oxidase deficiency associated with mucostasis. The gene discussed is FMO5; the disease is chronic granulomatous disease.