IL5 and asthma: Antigen-specific Th2 cells and their cytokines (such as IL-4Ra, IL-5, and IL-13), and inflammatory cells such eosinophils and mast cells are primary mediators of the pathological changes seen in asthma such as airway inflammation and airway hyper-responsiveness (AHR) (Hosoki et al., 2015; Wuhao et al., 2017).