The KEGG pathway enrichment analysis demonstrated that there are four signaling pathways, including phosphatidylinositol-3-kinase (PI3K)-AKT signaling pathway, pathway in cancer, Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, cytokine-cytokine receptor interaction, were highly associated to the predicted targets of circ003593 (Figure 6B). This evidence concerns the gene AKT1 and cancer.