Loss of cavin3 was demonstrated in lung, gastric, ovarian, and colorectal cancers (Zochbauer-Muller et al., 2005; Lee et al., 2008; Tong et al., 2010; Lee et al., 2011), suggesting the tumor suppressing role of cavin3 in these tumors. The gene discussed is CAVIN3; the disease is colorectal cancer.