Impaired proteostasis defines many neurodegenerative diseases, with accumulation of aggregates of malformed proteins being defining diagnostic features for many, such as α-synuclein for Parkinson’s and amyloid-β and tau for Alzheimer’s (Hetz and Mollereau, 2014; Kurtishi et al., 2019). The gene discussed is MAPT; the disease is Parkinson disease.