IL17A and ischemic stroke: Our previous study demonstrated that IL-17A remarkably increased both in the peri-infarct region and cerebrospinal fluid (CSF) of mice after 1-h middle cerebral artery occlusion/12-h reperfusion (1 h MCAO/R 12 h)-induced ischemic stroke, and the immunofluorescent staining also indicated that astrocytes were the main source of IL-17A in the brain of mice with ischemic stroke (Li S. et al., 2017).