GPX4 and Cognitive impairment: The greatest characteristic of AD patients is cognitive impairment, and neuronal deficits in AD, especially hippocampal neuronal damage with increased ferroptosis, which imply activation of the Nrf2/GPX4 signaling pathway, may also be the cause of cognitive impairment in TBI patients (Gómez-Isla et al., 1997; Yao et al., 2019).