Moreover, neuroinflammation linked to tau deposition has been well documented in mice transgenic for human mutant tau protein (Bellucci et al., 2004; Yoshiyama et al., 2007) or in transgenic rats expressing misfolded truncated tau protein derived from AD (Zilka et al., 2006; Stozicka et al., 2010). The gene discussed is MAPT; the disease is Alzheimer disease.