Studies have revealed that agonist activity at peroxisome proliferator-activated receptor-gamma (PPAR-γ) has beneficial effect in neurodegenerative diseases through upregulating PGC-1α expression and attenuating inflammation, oxidative stress, and mitochondrial dysfunction (Rona-Voros and Weydt, 2010). This evidence concerns the gene PPARG and neurodegenerative disease.