(ii) the CendR sequence of the polypeptide becomes exposed by hydrolysis of the protease (C-terminal); (iii) the CendR sequence binds to neuropilin-1 (NRP-1) on the cell surface, which becomes rapidly integrated into the cell to be subsequently excreted out by exosmosis, where it ‘infects’ other adjacent tumor cells for rapid infiltration into the tumor tissue. The gene discussed is NRP1; the disease is neoplasm.