TGFB1 and neoplasm: (2013) found that prior to nano-drug treatment, pre-injection of the TGF-β signal inhibitor, LY364947, was able to reform the pancreatic tissue microenvironment, reducing the density of the tumor stroma and reducing coverage of blood vessels by adventitial fibroblasts in the tumor microenvironment, promoting penetration of nano-drug into tumor tissues and enhancing the curative effect of nano-drug treatment (Figure 7).