For example, transforming growth factor-β (TGF-β), interleukin 10 (IL10), and vascular epidermal growth factor (VEGF) (Phuengkham et al., 2019) secreted by tumor associated macrophages (TAMs), regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) which have the effect of negatively regulating the body’s immune response to tumors and promoting tumor growth. This evidence concerns the gene TGFB1 and neoplasm.