Patients with APS-3 showed higher age (p = 0.001), age of onset of diabetes (p = 0.006), VAI (p = 0.008) and TSH (p = 0.004) and lower total insulin as U/day (p < 0.001) and U/Kg (p = 0.001) and irisin (p = 0.002) compared to T1DM (Table 1). This evidence concerns the gene INS and type 1 diabetes mellitus.