Lambadiari et al. showed that the insulin-sensitizing effect of thyroid hormone improved glycaemia, insulin sensitivity indices and peripheral glucose uptake and disposal in subjects with type 2 diabetes and that administration of small subthyrotoxic doses of thyroxin to treatment-naive diabetic euthyroid subjects improved glucose disposal in forearm muscle and overall insulin sensitivity, suggesting its therapeutic importance in subjects with insulin resistance by reducing the burden of hyperglycaemia and possibly the long-term complications of diabetes [38]. This evidence concerns the gene INS and Hyperglycemia.