In addition, treatment with mTOR inhibitors conferred a significant survival advantage in overall survival at 1-, 3- and 5-years post-transplant (RR: 1.07, 1.1, and 1.18, respectively), and a significantly lower rate of HCC recurrence (RR: 0.67) compared with conventional CNI-based immunosuppression. This evidence concerns the gene MTOR and hepatocellular carcinoma.