Overall, regardless of whether the B cells were harvested from the periphery or the spleen, the B cell subsets from LC patients, to varying extents, expressed higher levels of CD95, FcRL4, CD86, CD71, CD11c, CXCR3, and CCR6 than those from HC subjects (Fig. S2A–D and Fig. 2d–g). Here, TFRC is linked to laryngotracheoesophageal cleft.