The persistent activation of splenic Tfh cells may enhance B cell maturation in cirrhotic patients26; therefore, we analyzed the activation-associated markers (CD95, FcRL4, CD86, and CD71) and migration-associated markers (CD11c, CXCR3, and CCR6) on the B cell subsets in LC patients (Table 2, panels 2 and 3). This evidence concerns the gene FCRL4 and laryngotracheoesophageal cleft.