Overall, regardless of whether the B cells were harvested from the periphery or the spleen, the B cell subsets from LC patients, to varying extents, expressed higher levels of CD95, FcRL4, CD86, CD71, CD11c, CXCR3, and CCR6 than those from HC subjects (Fig. S2A–D and Fig. 2d–g). The gene discussed is CXCR3; the disease is laryngotracheoesophageal cleft.