CILP2 and neoplasm: To determine the role of CILP2 in CRC, we first analyzed CILP2 gene expression in 50 patients’ samples with paired adjacent normal tissues in TCGA cohort, and the results suggested that CILP2 gene was overexpressed statistically significant in tumor samples compared to paired adjacent normal tissues (Fig. 1a, b; fold change = 3.412; P < 0.001; Table 1).