BSCL2 and severe neurodegenerative syndrome with lipodystrophy: Conditions associated with variants in the BSCL2/seipin gene include progressive encephalopathy with/without lipodystrophy (PELD), also called Celia’s encephalopathy (MIM#615924) and congenital general lipodystrophy type 2 (CGL2) [2, 5].