In addition, the recently observed reduction of serum aldosterone in L‐NAME‐hypertension by ivabradine [4] and the ivabradine’s interference with the renin–angiotensin system in terms of attenuation of the angiotensin II type 1 receptor or angiotensin‐converting enzyme [10] protein expression and diminution of serum angiotensin II [8] may also contribute to cardiovascular protection. The gene discussed is AGT; the disease is Hypertension.