To determine whether CXCR5+PD‐1+ CD8 T cells could play a similar important role in humans, we studied the localization, phenotype, and functionality of CXCR5+PD‐1+ CD8 T cells in HC and patients with hematologic malignancies with varying responses to PD‐1 ICB therapy. Here, CXCR5 is linked to hematologic disorder.