Systemic and local changes in immune responses that includeimpaired CD4+ T cells have been frequently reportedas contributing factors in endometriosis pathogenesis (6-8).CD4+ T cells exert their potential role in endometriosis through cytokines that are involved in implantation andproliferation of ectopic endometrial cells, inflammationand angiogenesis (7, 9-12). The gene discussed is CD4; the disease is endometriosis.