The methylation modification of m6A mainly involves three processes: RNA methylation mediated by METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, RNA demethylation mediated by FTO, ALKBH5, and ALKBH3, and downstream RNA translation and degradation involving YTHDF1/2/3 and ELAVL1.Using transcriptome sequencing, Chen et al19 found that METTL3 was highly expressed in human hepatoma cells, whereby it was highly related to the poor prognosis of hepatoma patients; SOCS2 gene was identified as a causal target of METTL3‐mediated m6A modification. This evidence concerns the gene METTL3 and hepatocellular carcinoma.