The recurrently mutated genes in our cohort of cancers from nonsmokers were CTNNA3, EIF3A, EP300, FXR1, NEK8, NOTCH1, PIK3CA, PKHD1L1, PTCHD2, RALGAPB, SPEN, and UBR4. Nonsmokers had fewer TP53 mutations than smokers. Here, PIK3CA is linked to cancer.