Available data suggest that PXR-dependent activation of xenobiotic metabolism-related gene expression is augmented by activated β-catenin in human HepaRG hepatoma cells (Thomas et al. 2015), while no pronounced effects of a Ctnnb1 knockout on PXR-dependent target gene induction were visible in mouse liver (Braeuning et al. 2009). This evidence concerns the gene NR1I2 and hepatocellular carcinoma.