Importantly, the combination of sulfasalazine and sorafenib has synergistic effect in inhibiting BCAT2 expression as well as promoting ferroptotic cancer cell death in vitro and in a couple of animal models including in subcutaneous pancreatic cancer model, orthotopic liver cancer model, as well as PDX hepatic carcinoma model. This evidence concerns the gene BCAT2 and familial pancreatic carcinoma.