Moreover, AMPK activator AICAR downregulated BCAT2 expression in both Aspc-1 and HepG2 cancer cells in a similar manner to erastin, sorafenib, or sulfasalazine, which can be reversed by AMPK inhibitor Compound C, further confirming that ferroptosis inducers downregulate BCAT2 expression through activating AMPK (Figs. 1E,  S4C, and S4D). This evidence concerns the gene BCAT2 and cancer.