These transgenic mice, obtained by backcrossing the 5x-fAD mouse model of AD with MITRG xenotransplantation-compatible mice (hCSF1, hCSF2, hTPO, Rag2 knockout, il2rγ knockout), were specifically developed to examine the functional behavior of transplanted human microglia in vivo40. Here, IL2RG is linked to Alzheimer disease.