ABCB11 and hyperinsulinemic hypoglycemia, familial, 4: To compare prime editing to base editing, we selected two severe pathogenic G → A mutations suitable for correction by adenine base editors (ABEs): the BSEP-deficiency mutation ABCB11R1153H and the alpha-1 antitrypsin deficiency ZZ-genotype (SERPINA1E342K)10,12,13.