To compare prime editing to base editing, we selected two severe pathogenic G → A mutations suitable for correction by adenine base editors (ABEs): the BSEP-deficiency mutation ABCB11R1153H and the alpha-1 antitrypsin deficiency ZZ-genotype (SERPINA1E342K)10,12,13. The gene discussed is SERPINA1; the disease is hyperinsulinemic hypoglycemia, familial, 4.