AKT1 and hepatocellular carcinoma: The above observations of CLCF1 upregulation in HCC cells resistant to sorafenib, along with the participation of PI3K/AKT signaling in the regulation of aerobic glycolysis in HCC cells, prompted us to speculate that CLCF1 contributes to the enhanced rate of glycolysis in HCC cells resistant to sorafenib.