Overexpression of miR-30a-5p greatly inhibited the growth of HepG2-S-R tumors, which was effectively rescued by coexpression of the Flag-CLCF1 protein (Figs. 5c and S5C), supporting the functional importance of the miR-30a-5p/CLCF1 axis in the regulation of tumorigenesis in sorafenib-resistant HCC cells. The gene discussed is CLCF1; the disease is hepatocellular carcinoma.